Bone substitutes in orthopaedic surgery: from basic science to clinical practice. 2009 10(8):2067–73.Ĭampana V, Milano G, Pagano E, Barba M, Cicione C, Salonna G, et al. Osteogenic differentiation of human bone marrow mesenchymal stem cells seeded on melt based chitosan scaffolds for bone tissue engineering applications. 2018 7(6):1701061.Ĭosta-Pinto AR, Correlo VM, Sol PC, Bhattacharya M, Charbord P, Delorme B, et al. Current approaches to bone tissue engineering: the interface between biology and engineering. Biomaterials for bone regenerative engineering. Bone tissue engineering: state of the union. Development of clinically relevant scaffolds for vascularised bone tissue engineering. Bone calcium/phosphorus ratio determination using dual energy X-ray method. Sotiropoulou P, Fountos G, Martini N, Koukou V, Michail C, Kandarakis I, et al. Biomimetic porous scaffolds for bone tissue engineering. Bone tissue engineering: recent advances and challenges. These composite materials are combined to eliminate unfavourable properties and retain favourable properties.Īmini AR, Laurencin CT, Nukavarapu SP. To overcome these limitations, chitosan has been blended with other polymers (natural and synthetic), ceramics and other additives. Chitosan has many favourable properties however, limitations have hindered its application in bone tissue engineering. The application of chitosan-based biomaterials in the bone tissue engineering field has become increasingly popular among researchers. This review will focus on chitosan-based biomaterials that have been developed for bone tissue engineering. Chitosan has been blended in varying combinations with a variety of materials that include ceramics, synthetic polymers, natural polymers and other additives. By combining chitosan with other materials, the advantageous properties can potentially be retained or even enhanced and limiting properties can be mediated. Chitosan holds various favourable properties, yet the mechanical strength of pure chitosan scaffolds hinders its application in bone tissue engineering. Chitosan has been identified by many researchers as a suitable biomaterial for bone tissue engineering applications. Researchers have doubled their efforts to develop bone graft substitutes in order to overcome limitations that surround current bone loss treatment and the annual increase of cases dealing with bone loss and dysfunction. The bone is a highly dynamic tissue with the remarkable ability to remodel and is in a continuous cycle of resorption and renewal as a result of internal mediators and external mechanical demands.
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